HYNAPENES A, B AND C, NEW ANTICOCCIDIAL AGENTS PRODUCED BY Penicillium sp. I. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

NORIKO TABATA; HIROSHI TOMODA; ROKURO MASUMA; KATSUJI HANEDA; YUZURU IWAI; SATOSHI OMURA

doi:10.7164/antibiotics.46.1849

HYNAPENES A, B AND C, NEW ANTICOCCIDIAL AGENTS PRODUCED BY Penicillium sp.

I. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

NORIKO TABATA, HIROSHI TOMODA, ROKURO MASUMA, KATSUJI HANEDA, YUZURU IWAI, SATOSHI OMURA

著者情報

ジャーナルフリー

1993 年 46 巻 12 号 p. 1849-1853

DOI https://doi.org/10.7164/antibiotics.46.1849

詳細

抄録

Penicillium sp. FO-1611, a soil isolate, was found to produce a series of new anticoccidial compounds. Three active compounds, designated hynapenes A, B and C, were isolated from the fermetation broth of the producing strain by solvent extraction, silica gel column chromatography, gel filtration on Sephadex LH-20 and preparative HPLC. Hynapenes inhibited the growth of Eimeria tenella in an in vitro assay using BHK-21 cells as a host. No schizont in the cells was observed at concentrations ranging above 123μM, 34.7μM and 34.7μM for hynapenes A, B and C, respectively.

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