SYNTHESIS OF 3-EPISIASTATIN B ANALOGUES HAVING ANTI-INFLUENZA VIRUS ACTIVITY

YOSHIO NISHIMURA; YOJI UMEZAWA; SHINICHI KONDO; TOMIO TAKEUCHI; KEIJI MORI; ISAO KIJIMA-SUDA; KENKICHI TOMITA; KANETSU SUGAWARA; KIYOTO NAKAMURA

doi:10.7164/antibiotics.46.1883

YOSHIO NISHIMURA, YOJI UMEZAWA, SHINICHI KONDO, TOMIO TAKEUCHI, KEIJI MORI, ISAO KIJIMA-SUDA, KENKICHI TOMITA, KANETSU SUGAWARA, KIYOTO NAKAMURA

著者情報

ジャーナルフリー

1993 年 46 巻 12 号 p. 1883-1889

DOI https://doi.org/10.7164/antibiotics.46.1883

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抄録

Two epimers of siastatin B, 3-episiastatin B (3) and 3, 4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.

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