5-N-ACETYLARDEEMIN, A NOVEL HETEROCYCLIC COMPOUND WHICH REVERSES MULTIPLE DRUG RESISTANCE IN TUMOR CELLS

I. TAXONOMY AND FERMENTATION OF THE PRODUCING ORGANISM AND BIOLOGICAL ACTIVITY

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The ardeemins are a new family of secondary metabolites produced by submerged fermentation of a fungus which was isolated from a soil sample collected in Brazil. Based on taxonomic studies, the producing culture was identified as Aspergillus fischeri var. brasiliensis strain AB 1826M-35. 5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent vinblastine in multidrug resistant human tumor cells.