SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF ALANINE-EXCHANGED ANALOGS OF PRADIMICIN A
1993 年 46 巻 3 号 p. 500-506
詳細
1993 年 46 巻 3 号 p. 500-506
A series of pradimicin analogs were designed and synthesized to investigate the effect of the amino acid side chain on the antifungal activity. The alanine-exchanged analogs (3a-3q) were synthesized from 4'-N-Cbz-pradimic acid by coupling with appropriate amino acids or their equivalents followed by deblocking. All the D-α-amino acid derivatives except D-proline analog, 3k retained the antifungal activity.
