NEW VIRGINIAMYCIN M1 DERIVATIVES: SYNTHESIS, CHOLECYSTOKININ BINDING INHIBITORY AND ANTIMICROBIAL PROPERTIES

Y. K. TONY LAM; PING DAI; DEBORAH L. ZINK; ALISON J. SMITH; NAILIN W. LEE; STEPHEN FREEDMAN; MICHAEL J. SALVATORE

doi:10.7164/antibiotics.46.623

NEW VIRGINIAMYCIN M₁ DERIVATIVES: SYNTHESIS, CHOLECYSTOKININ BINDING INHIBITORY AND ANTIMICROBIAL PROPERTIES

Y. K. TONY LAM, PING DAI, DEBORAH L. ZINK, ALISON J. SMITH, NAILIN W. LEE, STEPHEN FREEDMAN, MICHAEL J. SALVATORE

著者情報

ジャーナルフリー

1993 年 46 巻 4 号 p. 623-630

DOI https://doi.org/10.7164/antibiotics.46.623

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抄録

Fifteen 13-ester, 13-carbanilate and 15-hydroxy derivatives of virginiamycin M₁ were synthesized and evaluated for their abilities to inhibit a) binding to the cholecystokinin receptor subtypes in guinea-pig brain (CCK-B) and rat pancreas (CCK-A), and b) microbial growth.

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