VERUCOPEPTIN, A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

YUJI NISHIYAMA; KOKO SUGAWARA; KOJI TOMITA; HARUAKI YAMAMOTO; HIDEO KAMEI; TOSHIKAZU OKI

doi:10.7164/antibiotics.46.921

VERUCOPEPTIN, A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA

I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

YUJI NISHIYAMA, KOKO SUGAWARA, KOJI TOMITA, HARUAKI YAMAMOTO, HIDEO KAMEI, TOSHIKAZU OKI

著者情報

ジャーナルフリー

1993 年 46 巻 6 号 p. 921-927

DOI https://doi.org/10.7164/antibiotics.46.921

詳細

抄録

A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It showed potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D×1 treatment schedule.

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