The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
EUPENIFELDIN, A NOVEL CYTOTOXIC BISTROPOLONE FROM Eupenicillium brefeldianum
FRIEDRICH MAYERL, QI GAO, STELLA HUANG, STEVEN E. KLOHR, JAMES A. MATSON, DONALD R. GUSTAVSON, DOLORES M. PIRNIK, RONALD L. BERRY, CRAIG FAIRCHILD, WILLIAM C. ROSE
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1993 Volume 46 Issue 7 Pages 1082-1088

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Abstract
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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