THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF Phoma IV. PREPARATION OF FLUORINATED SQUALESTATINS BY DIRECTED BIOSYNTHESIS

RICHARD J. P. CANNELL; MICHAEL J. DAWSON; RICHARD S. HALE; RICHARD M. HALL; DAVID NOBLE; SÉAN LYNN; NICHOLAS L. TAYLOR

doi:10.7164/antibiotics.46.1381

THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF Phoma

IV. PREPARATION OF FLUORINATED SQUALESTATINS BY DIRECTED BIOSYNTHESIS

RICHARD J. P. CANNELL, MICHAEL J. DAWSON, RICHARD S. HALE, RICHARD M. HALL, DAVID NOBLE, SÉAN LYNN, NICHOLAS L. TAYLOR

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 9 Pages 1381-1389

DOI https://doi.org/10.7164/antibiotics.46.1381

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Abstract

Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.

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