NOVEL ANTIBIOTICS SF2738A, B AND C, AND THEIR ANALOGS PRODUCED BY Streptomyces sp.
1994 年 47 巻 12 号 p. 1385-1394
詳細
1994 年 47 巻 12 号 p. 1385-1394
Three new antibiotics SF2738A, B and C, and their analogs were isolated from the culture broth of Streptomyces sp. The antibiotics are active against Gram-positive bacteria, Gram-negative bacteria and fungi, and exhibited cytotoxic activity against P388 murine leukemia cells with IC50 values of 0.08, 0.25 and 7.5 μg/ml, respectively. Their structures were determined by spectral analyses and chemical conversion. Especially, the structure of SF2738A was confirmed to be (E)-((4-methoxy-5-methylthio-2-(2-pyridyl)pyridin-6-yl)methylene)azanol by X-ray crystallographic analysis.
