BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR III. SYNTHESIS

SEIICHI TANAKA; TAKAYOSHI OKABE; SHIGERU NAKAJIMA; EISAKU YOSHIDA; HAJIME MORISHIMA

doi:10.7164/antibiotics.47.297

BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR

III. SYNTHESIS

SEIICHI TANAKA, TAKAYOSHI OKABE, SHIGERU NAKAJIMA, EISAKU YOSHIDA, HAJIME MORISHIMA

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 3 Pages 297-300

DOI https://doi.org/10.7164/antibiotics.47.297

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Abstract

In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3, 4-dimethoxybenzoyl)propionic acid and veratraldehyde or 3, 4-diacetoxy-benzaldehyde. The structure of BE-23372M was confirmed to be (E)-3-(3, 4-dihydroxybenzylidene)-5-(3, 4-dihydroxyphenyl)-2(3H)-furanone.

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