BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR
III. SYNTHESIS
1994 年 47 巻 3 号 p. 297-300
詳細
1994 年 47 巻 3 号 p. 297-300
In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3, 4-dimethoxybenzoyl)propionic acid and veratraldehyde or 3, 4-diacetoxy-benzaldehyde. The structure of BE-23372M was confirmed to be (E)-3-(3, 4-dihydroxybenzylidene)-5-(3, 4-dihydroxyphenyl)-2(3H)-furanone.
