PF1018, A NOVEL INSECTICIDAL COMPOUND PRODUCED BY Humicola sp.

Abstract

A new insecticidal compound PF1018 was isolated from the culture broth of Humicola sp. It exhibited insecticidal activity against a wide range of critical pest species. The structure of PF1018 was determined to be (7aS)-2-((2E)-l-hydroxy-3-((1S, 3aR, 4R, 5R, 7aR)-3a, 4, 5, 7a-tetrahydro-1, 3, 5, 7-tetramethyl-5, 1-((3S)-(Z)-2, 3-dimethylpropeno)-1H-inden-4-yl)-2-propenylidene)pyrrolizidine1, 3-dione, by NMR spectral analyses coupled with X-ray crystallographic analysis and chemical degradation study.