STRUCTURE-ACTIVITY RELATIONSHIP AMONG POLYHYDRO DERIVATIVES OF TYLOSIN
1994 年 47 巻 5 号 p. 581-587
詳細
1994 年 47 巻 5 号 p. 581-587
Tetra-, hexa-and octahydro derivatives of tylosin were prepared by the reduction of the conjugated double bond and carbonyl groups. Hydrogenation of the diene did not change the in vitro antimicrobial activity of compounds, while reduction of carbonyls causes small or complete loss of activity.
