The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
THE MNIOPETALS, NEW INHIBITORS OF REVERSE TRANSCRIPTASES FROM A Mniopetalum species (Basidiomycetes)
I. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES
ANDREA KUSCHELTIMM ANKEROBERT VELTENDÖRTE KLOSTERMEYERWOLFGANG STEGLICHBERNHARD KÖNIG
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1994 Volume 47 Issue 7 Pages 733-739

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Abstract

Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a Canadian Mniopetalum species. They were named mniopetals A, B, C, D, E and F. Their structures were elucidated by spectroscopic methods. The compounds, in addition to their inhibitory activities on reverse transcriptases, exhibit antimicrobial and cytotoxic properties.

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© Japan Antibiotics Research Association
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