The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PNEUMOCANDIN D0, A NEW ANTIFUNGAL AGENT AND POTENT INHIBITOR OF Pneumocystis carinii
SANDRA A. MORRISROBERT E. SCHWARTZDAVID F. SESINPRAKASH MASUREKARTHOMAS C. HALLADADENNIS M. SCHMATZKENNETH BARTIZALOTTO D. HENSENSDEBORAH L. ZINK
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1994 Volume 47 Issue 7 Pages 755-764

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Abstract

Pneumocandin D0 (9), a new member of the echinocandin class of antifungal agents, has been isolated as a minor constituent from fermentation broths of the filamentous fungi Zalerion arboricola (ATCC 20957). The structure of 9 has been determined mainly on the basis of spectroscopic analysis and by comparison with published data for similar compounds. To date, pneumocandin D0 has been found to be the most potent inhibitor of Pneumocystis carinii development in vivo within the natural-occuring echinocandin family of antifungal agents.

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