PNEUMOCANDIN D0, A NEW ANTIFUNGAL AGENT AND POTENT INHIBITOR OF Pneumocystis carinii

SANDRA A. MORRIS; ROBERT E. SCHWARTZ; DAVID F. SESIN; PRAKASH MASUREKAR; THOMAS C. HALLADA; DENNIS M. SCHMATZ; KENNETH BARTIZAL; OTTO D. HENSENS; DEBORAH L. ZINK

doi:10.7164/antibiotics.47.755

PNEUMOCANDIN D₀, A NEW ANTIFUNGAL AGENT AND POTENT INHIBITOR OF Pneumocystis carinii

SANDRA A. MORRIS, ROBERT E. SCHWARTZ, DAVID F. SESIN, PRAKASH MASUREKAR, THOMAS C. HALLADA, DENNIS M. SCHMATZ, KENNETH BARTIZAL, OTTO D. HENSENS, DEBORAH L. ZINK

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 7 Pages 755-764

DOI https://doi.org/10.7164/antibiotics.47.755

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Abstract

Pneumocandin D₀ (9), a new member of the echinocandin class of antifungal agents, has been isolated as a minor constituent from fermentation broths of the filamentous fungi Zalerion arboricola (ATCC 20957). The structure of 9 has been determined mainly on the basis of spectroscopic analysis and by comparison with published data for similar compounds. To date, pneumocandin D₀ has been found to be the most potent inhibitor of Pneumocystis carinii development in vivo within the natural-occuring echinocandin family of antifungal agents.

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