The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp. M6222
II. Structure Determination of Stachybocins A, B and C
KIYOSHI OGAWAMASATO NAKAMURAMITSUO HAYASHISATOSHI YAGINUMASYUJI YAMAMOTOKAZUO FURIHATAKAZUO SHIN-YAHARUO SETO
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1995 年 48 巻 12 号 p. 1396-1400

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The structures of Stachybocins A, B and C, new endothelin receptor antagonists, were determined by NMR spectral analysis using pulse-field-gradient techniques. Stachybocin A consists of two spirobenzofuran units each fused to a substituted decalin, which were connected by a lysine residue. Stachybocins B and C are derivatives of Stachybocin A with an additional hydroxy group at the same position in the different decalin unit.

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