RS-22A, B and C: New Macrolide Antibiotics from Streptomyces violaceusniger I. Taxonomy, Fermentation, Isolation and Biological Activities

MAKOTO UBUKATA; NORIO SHIRAISHI; KIMIE KOBINATA; TAKUJI KUDO; ISAMU YAMAGUCHI; HIROYUKI OSADA; YIN-CHU SHEN; KIYOSHI ISONO

doi:10.7164/antibiotics.48.289

RS-22A, B and C: New Macrolide Antibiotics from Streptomyces violaceusniger

I. Taxonomy, Fermentation, Isolation and Biological Activities

MAKOTO UBUKATA, NORIO SHIRAISHI, KIMIE KOBINATA, TAKUJI KUDO, ISAMU YAMAGUCHI, HIROYUKI OSADA, YIN-CHU SHEN, KIYOSHI ISONO

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 4 Pages 289-292

DOI https://doi.org/10.7164/antibiotics.48.289

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Abstract

Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.

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