Inhibition of Phosphatidylinositol-speciflc Phospholipase C Activity by Fluvirucin B2
1995 年 48 巻 5 号 p. 387-390
詳細
1995 年 48 巻 5 号 p. 387-390
We isolated fluvirucin B2 from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6 μg/ml. Fluvirucin B2 also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.
