RES-1149-1 and -2, Novel Non-peptidic Endothelin Type B Receptor Antagonists Produced by Aspergillus sp. I. Taxonomy of Producing Strain, Fermentation, Isolation, and Physico-chemical and Biological Properties

TATSUHIRO OGAWA; KATSUHIKO ANDO; TAKEO TANAKA; YOUICHI UOSAKI; YUZURU MATSUDA

doi:10.7164/antibiotics.49.1

RES-1149-1 and -2, Novel Non-peptidic Endothelin Type B Receptor Antagonists Produced by Aspergillus sp.

I. Taxonomy of Producing Strain, Fermentation, Isolation, and Physico-chemical and Biological Properties

TATSUHIRO OGAWA, KATSUHIKO ANDO, TAKEO TANAKA, YOUICHI UOSAKI, YUZURU MATSUDA

著者情報

ジャーナルフリー

1996 年 49 巻 1 号 p. 1-5

DOI https://doi.org/10.7164/antibiotics.49.1

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抄録

RES-1149-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the cultured broth of a fungus, Aspergillus sp. RE-1149. RES-1149-1 and -2 selectively inhibited the ET-1 binding to endothelin type B receptor (ET_B receptor) with IC₅₀ values of 1.5μM and 20μM, respectively. Taxonomy of producing strains, fermentation, isolation, and physico-chemical properties of RES-1149-1 and -2 are described.

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