The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Fusaricidin A, a New Depsipeptide Antibiotic Produced by Bacillus polymyxa KT-8
Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity
YOSHIO KAJIMURAMIYUKI KANEDA
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Volume 49 (1996) Issue 2 Pages 129-135

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Abstract

Fusaricidin A, a new depsipeptide antibiotic, was isolated from the culture broth of Bacillus polymyxa KT-8 obtained from the rhizosphere of garlic suffering from the basal rot caused by Fusarium oxysporum. The structure of fusaricidin A was determined by ID and 2D NMR and MS experiments coupled with amino acid analysis to be a hexadepsipeptide containing 15-guanidino-3-hydroxypentadecanoic acid as a side chain. The absolute configuration of each amino acid residue was determined by chiral HPLC. Fusaricidin A is active against fungi and Gram-positive bacteria.

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