Andrastins A-C, New Protein Farnesyltransferase Inhibitors Produced by Penidllium sp. FO-3929 I. Producing Strain, Fermentation, Isolation, and Biological Activities

SATOSHI OMURA; JUNJI INOKOSHI; RYUJI UCHIDA; KAZURO SHIOMI; ROKURO MASUMA; TOMOYA KAWAKUBO; HARUO TANAKA; YUZURU IWAI; SEIJI KOSEMURA; SHOSUKE YAMAMURA

doi:10.7164/antibiotics.49.414

Andrastins A-C, New Protein Farnesyltransferase Inhibitors Produced by Penidllium sp. FO-3929

I. Producing Strain, Fermentation, Isolation, and Biological Activities

SATOSHI OMURA, JUNJI INOKOSHI, RYUJI UCHIDA, KAZURO SHIOMI, ROKURO MASUMA, TOMOYA KAWAKUBO, HARUO TANAKA, YUZURU IWAI, SEIJI KOSEMURA, SHOSUKE YAMAMURA

Author information

SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute
JUNJI INOKOSHI
School of Pharmaceutical Sciences, Kitasato University
RYUJI UCHIDA
Research Center for Biological Function, The Kitasato Institute
KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute
ROKURO MASUMA
Research Center for Biological Function, The Kitasato Institute
TOMOYA KAWAKUBO
Research Center for Biological Function, The Kitasato Institute
HARUO TANAKA
School of Pharmaceutical Sciences, Kitasato University
YUZURU IWAI
Research Center for Biological Function, The Kitasato Institute
SEIJI KOSEMURA
Department of Chemistry, Faculty of Science and Technology, Keio University
SHOSUKE YAMAMURA
Department of Chemistry, Faculty of Science and Technology, Keio University

JOURNAL FREE ACCESS

1996 Volume 49 Issue 5 Pages 414-417

DOI https://doi.org/10.7164/antibiotics.49.414

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Abstract

New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penidllium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC₅₀ of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3μM, respectively.

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