Synthesis and Modification of a Novel 1β-Methyl Carbapenem Antibiotic, S-4661

YASUYOSHI ISO; TADASHI IRIE; TSUTOMU IWAKI; MAKOTO KII; YUJI SENDO; KIYOSHI MOTOKAWA; YASUHIRO NISHITANI

doi:10.7164/antibiotics.49.478

YASUYOSHI ISO, TADASHI IRIE, TSUTOMU IWAKI, MAKOTO KII, YUJI SENDO, KIYOSHI MOTOKAWA, YASUHIRO NISHITANI

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ジャーナルフリー

1996 年 49 巻 5 号 p. 478-484

DOI https://doi.org/10.7164/antibiotics.49.478

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We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

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