Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649 II. Physicochemical Properties and Structural Elucidation

SATOSHI TAKAMATSU; YONG-PIL KIM; TAKAMARO KOMIYA; TOSHIAKI SUNAZUKA; MASAHIKO HAYASHI; HARUO TANAKA; KANKI KOMIYAMA; SATOSHI OMURA

doi:10.7164/antibiotics.49.635

Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649

II. Physicochemical Properties and Structural Elucidation

SATOSHI TAKAMATSU, YONG-PIL KIM, TAKAMARO KOMIYA, TOSHIAKI SUNAZUKA, MASAHIKO HAYASHI, HARUO TANAKA, KANKI KOMIYAMA, SATOSHI OMURA

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ジャーナルフリー

1996 年 49 巻 7 号 p. 635-638

DOI https://doi.org/10.7164/antibiotics.49.635

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A new growth inhibitor of IL-6 responsive MH60 cells, chlovalicin (MW; 332, C₁₆H₂₅O₅Cl), was found in cultures of Sporothrix sp. FO-4649, together with a known sesquiterpene, ovalicin. The structure of chlovalicin was elucidated by spectroscopic methods. Chlovalicin possesses a chlorinated methylene moiety at the C-1 position, and it corresponds to halogenated products derived from the epoxide ring attached to the C-1 position of ovalicin. The absolute configuration of chlovalicin was clarified as IS, 2R, 35, I'S, 2'R by chemical transformation from ovalicin.

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