Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. FO-4259

II. Structure Elucidation

Abstract

The structures of new acetylcholinesterase inhibitors, arisugacins A and B, were elucidated by NMR study. Arisugacins have a (4aR, 6aR, 12aS', 12bS)-4a, 6, 6a, 12, 12a, 12b-hexahydro-4a, 12a-dihydroxy-4, 4, 6a, 12b-tetramethyl-4H, 11H-naphtho[2, 1-b]pyrano[3, 4-e]pyran-1, 11(5H)-dione moiety in common and 3, 4-dimethoxyphenyl or 4-methoxyphenyl residues are attached to C-9 of the moiety.