Pyrrolosporin A, a New Antitumor Antibiotic from Micromonospora sp. C39217-R109-7 II. Isolation, Physico-chemical Properties, Spectroscopic Study and X-ray Analysis

DANIEL R. SCHROEDER; KIMBERLY L. COLSON; STEVE E. KLOHR; MIKE S. LEE; JAMES A. MATSON; LINDA S. BRINEN; JON CLARDY

doi:10.7164/antibiotics.49.865

Pyrrolosporin A, a New Antitumor Antibiotic from Micromonospora sp. C39217-R109-7

II. Isolation, Physico-chemical Properties, Spectroscopic Study and X-ray Analysis

DANIEL R. SCHROEDER, KIMBERLY L. COLSON, STEVE E. KLOHR, MIKE S. LEE, JAMES A. MATSON, LINDA S. BRINEN, JON CLARDY

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ジャーナルフリー

1996 年 49 巻 9 号 p. 865-872

DOI https://doi.org/10.7164/antibiotics.49.865

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Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-a-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (CIS). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.

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