Kurasoins A and B, New Protein Earnesyltransferase Inhibitors Produced by Paedlomyces sp. FO-3684 II. Structure Elucidation and Total Synthesis

RYUJI UCHIDA; KAZURO SHIOMI; TOSHIAKI SUNAZUKA; JUNJI INOKOSHI; AI NISHIZAWA; TOMOYASU HIROSE; HARUO TANAKA; YUZURU IWAI; SATOSHI OMURA

doi:10.7164/antibiotics.49.886

Kurasoins A and B, New Protein Earnesyltransferase Inhibitors Produced by Paedlomyces sp. FO-3684

II. Structure Elucidation and Total Synthesis

RYUJI UCHIDA, KAZURO SHIOMI, TOSHIAKI SUNAZUKA, JUNJI INOKOSHI, AI NISHIZAWA, TOMOYASU HIROSE, HARUO TANAKA, YUZURU IWAI, SATOSHI OMURA

著者情報

RYUJI UCHIDA
Research Center for Biological Function, The Kitasato Institute
KAZURO SHIOMI
Research Center for Biological Function, The Kitasato Institute
TOSHIAKI SUNAZUKA
School of Pharmaceutical Sciences, Kitasato University
JUNJI INOKOSHI
School of Pharmaceutical Sciences, Kitasato University
AI NISHIZAWA
School of Pharmaceutical Sciences, Kitasato University
TOMOYASU HIROSE
School of Pharmaceutical Sciences, Kitasato University
HARUO TANAKA
School of Pharmaceutical Sciences, Kitasato University
YUZURU IWAI
Research Center for Biological Function, The Kitasato Institute
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute

ジャーナルフリー

1996 年 49 巻 9 号 p. 886-889

DOI https://doi.org/10.7164/antibiotics.49.886

詳細

抄録

The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-lpheny-1-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.

責任著者(Corresponding author)

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