Brasilinolide A, a New Macrolide Antibiotic Produced by Nocardia brasiliensis: Producing Strain, Isolation and Biological Activity

YASUSHI TANAKA; HISAYUKI KOMAKI; KATSUKIYO YAZAWA; YUZURU MIKAMI; AKIRA NEMOTO; TAKASHI TOJYO; KIYOSHI KADOWAKI; HIDEYUKI SHIGEMORI; JUN'ICHI KOBAYASHI

doi:10.7164/antibiotics.50.1036

Brasilinolide A, a New Macrolide Antibiotic Produced by Nocardia brasiliensis: Producing Strain, Isolation and Biological Activity

YASUSHI TANAKA, HISAYUKI KOMAKI, KATSUKIYO YAZAWA, YUZURU MIKAMI, AKIRA NEMOTO, TAKASHI TOJYO, KIYOSHI KADOWAKI, HIDEYUKI SHIGEMORI, JUN'ICHI KOBAYASHI

Author information

YASUSHI TANAKA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
HISAYUKI KOMAKI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
KATSUKIYO YAZAWA
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
YUZURU MIKAMI
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
AKIRA NEMOTO
Research Laboratory Higeta Shoyu Co., Ltd.
TAKASHI TOJYO
Research Laboratory Higeta Shoyu Co., Ltd.
KIYOSHI KADOWAKI
Research Laboratory Higeta Shoyu Co., Ltd.
HIDEYUKI SHIGEMORI
Faculty of Pharmaceutical Sciences, Hokkaido University
JUN'ICHI KOBAYASHI
Faculty of Pharmaceutical Sciences, Hokkaido University

JOURNAL FREE ACCESS

1997 Volume 50 Issue 12 Pages 1036-1041

DOI https://doi.org/10.7164/antibiotics.50.1036

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Abstract

A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).

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