Clonostachin, a Novel Peptaibol That Inhibits Platelet Aggregation
1997 年 50 巻 2 号 p. 105-110
詳細
1997 年 50 巻 2 号 p. 105-110
A novel peptaibol, designated clonostachin, was isolated from cultures of Clonostachys sp. F5898 by HP-20 and silica gel column chromatographies and reverse-phase HPLC. The structure of clonostachin was determined by Edman and chemical degradations, positive ion FAB-MS, EI-MS, and NMR analyses. Clonostachin was a linear tetradecapeptide with an N-terminal acetyl group and a C-terminal sugar alcohol. Clonostachin inhibited ADP-induced aggregation of human platelets by 80% at 150 μM.
