The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
Pterulinic Acid and Pterulone, Two Novel Inhibitors of NADH: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterula Species
I. Production, Isolation and Biological Activities
MICHAELA ENGLERTIMM ANKEOLOV STERNERULRICH BRANDT
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JOURNALS FREE ACCESS

1997 Volume 50 Issue 4 Pages 325-329

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Abstract

Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH: ubiquinone oxidoreductase (complex I).

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