Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities

ISAO MOMOSE; WEI CHEN; NAOKO KINOSHITA; HIRONOBU IINUMA; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.51.21

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1

I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities

ISAO MOMOSE, WEI CHEN, NAOKO KINOSHITA, HIRONOBU IINUMA, MASA HAMADA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 1 Pages 21-25

DOI https://doi.org/10.7164/antibiotics.51.21

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Abstract

A new antibiotic designated polyketomycin was isolated from the culture broth of Streptomyces sp. MK277-AF1. It was purified by ethyl acetate extraction, Sephadex LH-20 column chromatography and centrifugal partition chromatography (CPC). It inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Its MICs were less than 0.2μg/ml. Polyketomycin exhibited cytotoxic activity against nine tumor cell lines at concentrations of 0.9∼5.2μg/ml.

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