Diperamycin, a New Antimicrobial Antibiotic Produced by Streptomyces griseoaurantiacus MK393-AF2 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

NAOKI MATSUMOTO; ISAO MOMOSE; MAYA UMEKITA; NAOKO KINOSHITA; MAKOTO CHINO; HIRONOBU IINUMA; TSUTOMU SAWA; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.51.1087

Diperamycin, a New Antimicrobial Antibiotic Produced by Streptomyces griseoaurantiacus MK393-AF2

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

NAOKI MATSUMOTO, ISAO MOMOSE, MAYA UMEKITA, NAOKO KINOSHITA, MAKOTO CHINO, HIRONOBU IINUMA, TSUTOMU SAWA, MASA HAMADA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 12 Pages 1087-1092

DOI https://doi.org/10.7164/antibiotics.51.1087

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Abstract

Antibacterial antibiotics, diperamycin (1) was produced in the culture broth of Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of 1 suggested that 1 belonged to a member of cyclic hexadepsipeptide antibiotic.
Antibiotic 1 had potent inhibitory activity against various Gram-positive bacteria including Enterococcus seriolicida and methicillin-resistant Staphylococcus aureus.

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