Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora II. Structural Studies

HIROSHI HORI; YASUHIRO IGARASHI; TAKAYUKI KAJIURA; TAMOTSU FURUMAI; KAZUAKI HIGASHI; TADAYUKI ISHIYAMA; MASAKAZU URAMOTO; YOSHIMASA UEHARA; TOSHIKAZU OKI

doi:10.7164/antibiotics.51.402

Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora

II. Structural Studies

HIROSHI HORI, YASUHIRO IGARASHI, TAKAYUKI KAJIURA, TAMOTSU FURUMAI, KAZUAKI HIGASHI, TADAYUKI ISHIYAMA, MASAKAZU URAMOTO, YOSHIMASA UEHARA, TOSHIKAZU OKI

Author information

HIROSHI HORI
Faculty of Agriculture, Tamagawa University
YASUHIRO IGARASHI
Biotechnology Research Center, Toyama Prefectural University
TAKAYUKI KAJIURA
Biotechnology Research Center, Toyama Prefectural University
TAMOTSU FURUMAI
Biotechnology Research Center, Toyama Prefectural University
KAZUAKI HIGASHI
Faculty of Agriculture, Tamagawa University
TADAYUKI ISHIYAMA
Faculty of Agriculture, Tamagawa University
MASAKAZU URAMOTO
Faculty of Agriculture, Tamagawa University
YOSHIMASA UEHARA
Department of Bioactive Molecules, National Institute of Infectious Diseases
TOSHIKAZU OKI
Biotechnology Research Center, Toyama Prefectural University

JOURNAL FREE ACCESS

1998 Volume 51 Issue 4 Pages 402-417

DOI https://doi.org/10.7164/antibiotics.51.402

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Abstract

The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B

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