PF1163A and B, New Antifungal Antibiotics Produced by Penicilium sp. II. Physico-chemical Properties and Structure Elucidation

TORU SASAKI; HIROSHI NOSE; AYAKO HOSOYA; SHIGEMI YOSHIDA; MAMI KAWAGUCHI; TAKASHI WATANABE; TAKAYUKI USUI; YASUO OHTSUKA; TAKASHI SHOMURA; SATOKO TAKANO; KUNIAKI TATSUTA

doi:10.7164/antibiotics.53.38

PF1163A and B, New Antifungal Antibiotics Produced by Penicilium sp.

II. Physico-chemical Properties and Structure Elucidation

TORU SASAKI, HIROSHI NOSE, AYAKO HOSOYA, SHIGEMI YOSHIDA, MAMI KAWAGUCHI, TAKASHI WATANABE, TAKAYUKI USUI, YASUO OHTSUKA, TAKASHI SHOMURA, SATOKO TAKANO, KUNIAKI TATSUTA

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 1 Pages 38-44

DOI https://doi.org/10.7164/antibiotics.53.38

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Abstract

The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF 1163A differs from PF1163B by having an additional hydroxyl group on the side chain.

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