Haematocin, a New Antifungal Diketopiperazine Produced by Nectria haematococca Berk, et Br. (880701a-l) Causing Nectria Blight Disease on Ornamental Plants

YOSHIKATSU SUZUKI; HIROSHI TAKAHASHI; YASUAKI ESUMI; TSUTOMU ARIE; TETSUICHIRO MORITA; HIROYUKI KOSHINO; JUN UZAWA; MASAKAZU URAMOTO; ISAMU YAMAGUCHI

doi:10.7164/antibiotics.53.45

YOSHIKATSU SUZUKI, HIROSHI TAKAHASHI, YASUAKI ESUMI, TSUTOMU ARIE, TETSUICHIRO MORITA, HIROYUKI KOSHINO, JUN UZAWA, MASAKAZU URAMOTO, ISAMU YAMAGUCHI

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YOSHIKATSU SUZUKI
The Institute of Physical and Chemical Research (RIKEN)
HIROSHI TAKAHASHI
Tamagawa University
YASUAKI ESUMI
The Institute of Physical and Chemical Research (RIKEN)
TSUTOMU ARIE
The Institute of Physical and Chemical Research (RIKEN)
TETSUICHIRO MORITA
The Institute of Physical and Chemical Research (RIKEN)
HIROYUKI KOSHINO
The Institute of Physical and Chemical Research (RIKEN)
JUN UZAWA
The Institute of Physical and Chemical Research (RIKEN)
MASAKAZU URAMOTO
Tamagawa University
ISAMU YAMAGUCHI
The Institute of Physical and Chemical Research (RIKEN)

JOURNAL FREE ACCESS

2000 Volume 53 Issue 1 Pages 45-49

DOI https://doi.org/10.7164/antibiotics.53.45

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Abstract

A new antifungal diketopiperazine named haematocin was isolated from the culture broth of Nectria haematococca Berk, et Br. (880701 a-1) causing blight disease on ornamental plants, Phalaenopsis spp. and Doritanopsis spp. Its structure was established by spectroscopic methods. Haematocin inhibited the germ-tube elongation and spore-germination of Pyricularia oryzae at the ED₅₀ values of 30μg/ml and 160μg/ml, respectively.

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