Arisugacins C and D, Novel Acetylcholinesterase Inhibitors and Their Related Novel Metabolites Produced by Penicillium sp. FO-4259-11

抄録

The mutant of Penicillium sp. FO-4259, an arisugacins A and B producing strain, was found to produce a series of metabolites, designated arisugacins C, D, E, F, G and H, which were structurally related to arisugacins A and B. These compounds were isolated from the culture broth and the physico-chemical and biological properties were examined. The IC₅₀ values of arisugacins C and D against acetylcholinesterase (AChE) were 2.5μM and 3.5μM, respectively. However arisugacins E, F, G and H did not inhibit AChE at 100μM. Though they showed only weak or no activity against AChE compared with arisugacins A and B, they may be useful for the study of the structure-activity relationship.