Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp. I. Taxonomy, Production, Isolation and Biological Properties

MASAYUKI IGARASHI; CHIGUSA HAYASHI; YOSHIKO HOMMA; SEIKO HATTORI; NAOKO KINOSHITA; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.53.1096

Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp.

I. Taxonomy, Production, Isolation and Biological Properties

MASAYUKI IGARASHI, CHIGUSA HAYASHI, YOSHIKO HOMMA, SEIKO HATTORI, NAOKO KINOSHITA, MASA HAMADA, TOMIO TAKEUCHI

著者情報

ジャーナルフリー

2000 年 53 巻 10 号 p. 1096-1101

DOI https://doi.org/10.7164/antibiotics.53.1096

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抄録

A novel 16-membered lactone antibiotic named tubelactomicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated MK703-102F1, was identified as a member of Nocardia. Tubelactomicin A was isolated from the culture broth by Diaion HP20 absorption, ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies and centrifugal liquid-liquid partition chromatography (CPC). Tubelactomicin A showed strong activity against acid-fast bacteria including the drug-resistant strains.

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