Microbial and Chemical Conversion of Antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3, Deamicetosyl Derivatives of Antibiotic K41

抄録

Antibiotic derivative K41-DAI, -DA2 and -DAS (2-4), deamicetosyl derivatives of antibiotic K41 (1), were prepared by acidic degradation of K41 and following hydrogenation reaction. K41-DA2 (3) showed comparable antimicrobial activities to K41 in vitro but not in vivo.