The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus
SHOHEI SAKUDAMAKOTO ONOHIROYUKI IKEDATAKEFUMI NAKAMURAYASUHITO INAGAKIRYU KAWACHIJIRO NAKAYAMAAKINORI SUZUKIAKIRA ISOGAIHIROMICHI NAGASAWA
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2000 Volume 53 Issue 11 Pages 1265-1271

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Abstract

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μM.

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