A New Antimitotic Substance, FR182877 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

BUNJI SATO; HIDEYUKI MURAMATSU; MICHIYO MIYAUCHI; YASUHIRO HORI; SHIGEHIRO TAKASE; MOTOHIRO HINO; SEIJI HASHIMOTO; HIROSHI TERANO

doi:10.7164/antibiotics.53.123

A New Antimitotic Substance, FR182877

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

BUNJI SATO, HIDEYUKI MURAMATSU, MICHIYO MIYAUCHI, YASUHIRO HORI, SHIGEHIRO TAKASE, MOTOHIRO HINO, SEIJI HASHIMOTO, HIROSHI TERANO

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ジャーナルフリー

2000 年 53 巻 2 号 p. 123-130

DOI https://doi.org/10.7164/antibiotics.53.123

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Using the characteristic morphological changes of mammalian cells, we screened novel antimitotic substances and found that a strain of Streptomyces sp. No.9885 produced FR182877. This substance was isolated from the culture broth by ethyl acetate extraction, silica gel column chromatography and ODS column chromatography. Structural studies on FR182877 suggested that it had a unique hexacyclic structure encompassing its highly strained double bond. FR182877 exhibited potent antitumor activities against murine ascitic tumor and solid tumor in vivo.

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