SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp.

I. Fermentation, Isolation and Properties

抄録

A novel, potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, designated SB-219383 has been isolated from Micromonospora sp. NCIMB 40684. The fermentation, isolation and some properties are described, whilst the structure determination is described in the succeeding paper¹⁾. SB-219383 showed competitive, inhibitory activity against a Staphylococcus tyrosyl tRNA synthetase, with an IC₅₀ of <1nM, and exhibited weak in vitro activity against some Streptococcus sp.