Luminacins: A Family of Capillary Tube Formation Inhibitors from Streptomyces sp.

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation

Abstract

A new family of capillary tube formation inhibitors, designated luminacins, has been discovered in the fermentation broth of a soil bacterium. The strain was identified as Streptomyces sp. Mer-VD1207 from taxonomic studies. By means of a series of chromatographic procedures, fourteen structurally related components, luminacins A₁, A₂, B₁, B₂, C₁, C₂, D, E₁, E₂, E₃, F, G₁, G₂, and H, were isolated, and their structures were elucidated on the basis of spectroscopic analyses.