Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia

I. Production, Isolation and Biological Activities

Abstract

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-β-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in MvlLu cells with an IC₅₀ value of 20.3 μM and inhibited histone deacetylase.