Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia II. Physico-chemical Properties and Structure Elucidation

YUHTA MASUOKA; KAZUO SHIN-YA; KAZUO FIMIHATA; HISAO MATSUMO; YUKIHIRO TAKEBAYASHI; KOJI NAGAI; KJEN-ICHI SUZUKI; YOICHI HAYAKAWA; HARUO SETO

doi:10.7164/antibiotics.53.793

Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia

II. Physico-chemical Properties and Structure Elucidation

YUHTA MASUOKA, KAZUO SHIN-YA, KAZUO FIMIHATA, HISAO MATSUMO, YUKIHIRO TAKEBAYASHI, KOJI NAGAI, KJEN-ICHI SUZUKI, YOICHI HAYAKAWA, HARUO SETO

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JOURNAL FREE ACCESS

2000 Volume 53 Issue 8 Pages 793-798

DOI https://doi.org/10.7164/antibiotics.53.793

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Abstract

The structure of diheteropeptin (1), a TGF-β-like active substance from Diheterospora chlamydosporia Q58044, was determined to be a new cyclotetrapeptide, cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S, 8R, 9R)-2-amino-8, 9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies.

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