Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus

RYUJI UCHIDA; HIROSHI TOMODA; MASAYOSHI ARAI; SATOSHI OMURA

doi:10.7164/antibiotics.54.882

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus

RYUJI UCHIDA, HIROSHI TOMODA, MASAYOSHI ARAI, SATOSHI OMURA

Author information

JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 882-889

DOI https://doi.org/10.7164/antibiotics.54.882

Details

Abstract

Chlorogentisylquinone, a new inhibitor of neutral Sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including ¹H, ¹³C, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral Sphingomyelinase activity of rat brain membranes with an IC₅₀ value of 1.2μM.

Content from these authors

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!