The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Bisabosquals, Novel Squalene Synthase Inhibitors
I. Taxonomy, Fermentation, Isolation and Biological Activities
KAZUYUKI MINAGAWASHUICHI KOUZUKIKAZUHIDE NOMURATAKAHIRO YAMAGUCHIYOSHIMI KAWAMURAKEISUKE MATSUSHIMAHIROYOSHI TANIKIKUO ISHIITATSUO TANIMOTOTOSHIYUKI KAMIGAUCHI
Author information
JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 890-895

Details
Abstract
In the course of screening for yeast squalene synthase inhibitors, bisabosqual A was isolated from the culture broth of Stachybotrys sp. RF-7260. The related compounds bisabosquals B, C and D were also isolated from Stachybotrys ruwenzoriensis RF-6853. Bisabosquals inhibited squalene synthases. IC50 values of bisabosqual A against the microsomal squalene synthases from Saccharomyces cerevisiae, Candida albicans, HepG2 cell and rat liver were 0.43, 0.25, 0.95 and 2.5μg/ml, respectively. Bisabosqual C exhibited inhibitory activities similar to bisabosqual A. Bisabosqual A showed broad spectrum antifungal activity in vitro.
Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top