A New Antibiotic CJ-17, 665 from Aspergillus ochraceus

YUTAKA SUGIE; HIDEO HIRAI; TAISUKE INAGAKI; MASARU ISHIGURO; YOON-JEONG KIM; YASUHIRO KOJIMA; TATSUO SAKAKIBARA; SHINICHI SAKEMI; AKEMI SUGIURA; YUMIKO SUZUKI; LORI BRENNAN; JOAN DUIGNAN; LIANG HSIUNG HUANG; JOYCE SUTCLIFFE; NAKAO KOJIMA

doi:10.7164/antibiotics.54.911

A New Antibiotic CJ-17, 665 from Aspergillus ochraceus

YUTAKA SUGIE, HIDEO HIRAI, TAISUKE INAGAKI, MASARU ISHIGURO, YOON-JEONG KIM, YASUHIRO KOJIMA, TATSUO SAKAKIBARA, SHINICHI SAKEMI, AKEMI SUGIURA, YUMIKO SUZUKI, LORI BRENNAN, JOAN DUIGNAN, LIANG HSIUNG HUANG, JOYCE SUTCLIFFE, NAKAO KOJIMA

Author information

YUTAKA SUGIE
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
HIDEO HIRAI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
TAISUKE INAGAKI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
MASARU ISHIGURO
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YOON-JEONG KIM
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YASUHIRO KOJIMA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
TATSUO SAKAKIBARA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
SHINICHI SAKEMI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
AKEMI SUGIURA
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
YUMIKO SUZUKI
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc.
LORI BRENNAN
PGRD, Groton Laboratories, Pfizer Inc.
JOAN DUIGNAN
PGRD, Groton Laboratories, Pfizer Inc.
LIANG HSIUNG HUANG
PGRD, Groton Laboratories, Pfizer Inc.
JOYCE SUTCLIFFE
PGRD, Groton Laboratories, Pfizer Inc.
NAKAO KOJIMA
Faculty of Pharmacy, Meijo University

JOURNAL FREE ACCESS

2001 Volume 54 Issue 11 Pages 911-916

DOI https://doi.org/10.7164/antibiotics.54.911

Details

Abstract

A new antibiotic, CJ-17, 665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25μg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.

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