Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554

HIDEAKI UI; KAZURO SHIOMI; YUUICHI YAMAGUCHI; ROKURO MASUMA; TOHRU NAGAMITSU; DAISUKE TAKANO; TOSHIAKI SUNAZUKA; MICHIO NAMIKOSHI; SATOSHI OMURA

doi:10.7164/antibiotics.54.234

Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554

HIDEAKI UI, KAZURO SHIOMI, YUUICHI YAMAGUCHI, ROKURO MASUMA, TOHRU NAGAMITSU, DAISUKE TAKANO, TOSHIAKI SUNAZUKA, MICHIO NAMIKOSHI, SATOSHI OMURA

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JOURNAL FREE ACCESS

2001 Volume 54 Issue 3 Pages 234-238

DOI https://doi.org/10.7164/antibiotics.54.234

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Abstract

A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-δ-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.

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