New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis

抄録

Five new type II manumycins, containing the hydroxyquinol mC₇N unit, asukamycins A-II, B-II, C-II, D-II, E-II, were discovered in cultures of Streptomyces nodosus ssp. asukaensis. The biosynthetic origin of the type II manumycins from the type I compounds, containing an epoxyquinol mC₇N unit, was deduced from the time course of production and proven by preparing [7'-¹³C] asukamycin A and demonstrating its incorporation into asukamycin A-II.