Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326 I. Taxonomy, Fermentation, Isolation and Biological Activities

MASAYOSHI ARAI; HIROSHI TOMODA; ATSUKO MATSUMOTO; YOKO TAKAHASHI; BODY H. WOODRUFF; NOBIKO ISHIGURO; SUSUMU KOSAYASHI; SATOSHI OMURA

doi:10.7164/antibiotics.54.554

Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326

I. Taxonomy, Fermentation, Isolation and Biological Activities

MASAYOSHI ARAI, HIROSHI TOMODA, ATSUKO MATSUMOTO, YOKO TAKAHASHI, BODY H. WOODRUFF, NOBIKO ISHIGURO, SUSUMU KOSAYASHI, SATOSHI OMURA

Author information

MASAYOSHI ARAI
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University
HIROSHI TOMODA
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University
ATSUKO MATSUMOTO
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University
YOKO TAKAHASHI
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University
BODY H. WOODRUFF
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University
NOBIKO ISHIGURO
Faculty of Pharmaceutical Sciences, Science University of Tokyo
SUSUMU KOSAYASHI
Faculty of Pharmaceutical Sciences, Science University of Tokyo
SATOSHI OMURA
The Kitasato Institute, and Kitasato Institute for Life Sciences, Kitasato University

JOURNAL FREE ACCESS

2001 Volume 54 Issue 7 Pages 554-561

DOI https://doi.org/10.7164/antibiotics.54.554

Details

Abstract

Streptomyces sp. WK-6326, a soil isolate, was found to produce an inhibitor of interleukin (IL)-4 signal transduction. Two structurally related compounds, a novel one designated deacetylravidomycin M and the known deacetylravidomycin, were isolated from the culture broth by solvent extraction, silica gel column chromatography and HPLC. Deacetylravidomycin M inhibited IL-4-induced CD23 expression in U937 cells without any cytotoxic effect, whereas deacetylravidomycin showed no inhibitory activity.

Corresponding author

Register with J-STAGE for free!