Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothnx sp. I. Production, Isolation and Biological Activity

RYO MURAKAMI; TAIJIRO TOMIKAWA; KAZUO SHIN-YA; JUNKO SHINOZAKI; TAKAYUKI KAJIURA; TAISEI KINOSHITA; ATSUSHI MIYAJIMA; HARUO SETO; YOICHI HAYAKAWA

doi:10.7164/antibiotics.54.710

Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothnx sp.

I. Production, Isolation and Biological Activity

RYO MURAKAMI, TAIJIRO TOMIKAWA, KAZUO SHIN-YA, JUNKO SHINOZAKI, TAKAYUKI KAJIURA, TAISEI KINOSHITA, ATSUSHI MIYAJIMA, HARUO SETO, YOICHI HAYAKAWA

著者情報

ジャーナルフリー

2001 年 54 巻 9 号 p. 710-713

DOI https://doi.org/10.7164/antibiotics.54.710

詳細

抄録

A new apoptosis inducer, ammocidin, was isolated from the culture broth of Saccharothnx sp. AJ9571. Ammocidin induced apoptotic cell death in Ras-dependent Ba/F3-V12 cells with an IC₅₀ of 66ng/ml. No cell death was observed in IL-3-dependent Ba/F3-V12 cells at less than 100μg/ml of ammocidin. Ammocidin significantly reduced the phosphorylation level of MAPK and S6K that mediate the anti-apoptotic function of Ras.

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